Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis,
cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a …

Background The Loeys–Dietz syndrome is a recently described autosomal dominant aortic-
aneurysm syndrome with widespread systemic involvement. The disease is characterized by …

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular
and physiologic processes including proliferation, differentiation, migration, cell survival …

Transforming growth factor βs (TGF-βs) are closely related ligands that have pleiotropic
activity on most cell types of the body. They act through common heterotetrameric TGF-β …

Transforming growth factor-β (TGF-β) is a secreted polypeptide that signals via receptor
serine/threonine kinases and intracellular Smad effectors. TGF-β inhibits proliferation and …

Signaling by transforming growth factor-β (TGF-β) superfamily ligands to the nucleus is
mediated by type I and type II receptors and the intracellular signal transducers, the Smads …

Many advanced tumors produce excessive amounts of Transforming Growth Factor-β (TGF-
β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically …

Marfan syndrome is an extracellular matrix disorder with cardinal manifestations in the eye,
skeleton and cardiovascular systems associated with defects in the gene encoding fibrillin …