To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

Limitation of infarct size by ischemic/pharmacological pre-and postconditioning involves
activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate …

Background—Brief interruptions of coronary blood flow paradoxically protect the heart from
subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as …

ATP-sensitive K+ (KATP) channels are therapeutic targets for several diseases, including
angina, hypertension, and diabetes. This is because stimulation of KATP channels is …

▪ Abstract Ischemic preconditioning is a phenomenon whereby exposure of the myocardium
to a brief episode of ischemia and reperfusion markedly reduces tissue necrosis induced by …

Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels
rather than sarcolemmal KATP (sarcKATP) channels are important as end effectors and/or …