Connecting the “dots”: from free radical lipid autoxidation to cell pathology and disease
Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is
increasingly implicated in various diseases but also recognized as a key part of normal cell …
increasingly implicated in various diseases but also recognized as a key part of normal cell …
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification
Natural products are an important source of new drugs for the treatment of various diseases.
However, developing natural product-based new medicines through random moiety …
However, developing natural product-based new medicines through random moiety …
Origin and fate of acrolein in foods
Acrolein is a highly toxic agent that may promote the occurrence and development of various
diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main …
diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main …
[HTML][HTML] Harmful chemicals emitted from electronic cigarettes and potential deleterious effects in the oral cavity
Use of electronic nicotine delivery systems (ENDS), such as electronic cigarettes (e-cigs), is
increasing across the US population and is particularly troubling due to their adoption by …
increasing across the US population and is particularly troubling due to their adoption by …
[HTML][HTML] Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives
Reactive carbonyl species (RCS) formed by lipidperoxidation as free forms or as enzymatic
and non-enzymatic conjugates are widely used as an index of oxidative stress. Besides …
and non-enzymatic conjugates are widely used as an index of oxidative stress. Besides …
Protein lipoxidation: basic concepts and emerging roles
Á Viedma-Poyatos, P González-Jiménez, O Langlois… - Antioxidants, 2021 - mdpi.com
Protein lipoxidation is a non-enzymatic post-translational modification that consists of the
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …
The knowns and unknowns in protein–metabolite interactions
I Kurbatov, G Dolgalev, V Arzumanian… - International Journal of …, 2023 - mdpi.com
Increasing attention has been focused on the study of protein–metabolite interactions (PMI),
which play a key role in regulating protein functions and directing an orchestra of cellular …
which play a key role in regulating protein functions and directing an orchestra of cellular …
Modification of proteins by reactive lipid oxidation products and biochemical effects of lipoxidation
CM Spickett, AR Pitt - Essays in Biochemistry, 2020 - portlandpress.com
Lipid oxidation results in the formation of many reactive products, such as small aldehydes,
substituted alkenals, and cyclopentenone prostaglandins, which are all able to form covalent …
substituted alkenals, and cyclopentenone prostaglandins, which are all able to form covalent …
ACR-based probe for the quantitative profiling of histidine reactivity in the human proteome
J Li, J Zhou, H Xu, K Tian, H Zhu, Y Chen… - Journal of the …, 2023 - ACS Publications
The quantitative profiling of residue reactivity in proteins promotes the discovery of covalent
druggable targets for precise therapy. Histidine (His) residues, accounting for more than …
druggable targets for precise therapy. Histidine (His) residues, accounting for more than …
Selenoprotein S: A versatile disordered protein
Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is
associated with various cellular functions, such as inflammatory processes, cellular stress …
associated with various cellular functions, such as inflammatory processes, cellular stress …