Human blood monocytes are heterogeneous and conventionally subdivided into two
subsets based on CD16 expression. Recently, the official nomenclature subdivides …

Historically tools and technologies facilitated scientific discoveries. Steroid hormone
research is not an exception. Unfortunately, the dramatic advancement of the field faded this …

Single-cell RNA sequencing (scRNA-seq) data are commonly affected by technical artifacts
known as" doublets," which limit cell throughput and lead to spurious biological conclusions …

New official nomenclature subdivides human monocytes into 3 subsets: the classical
(CD14++ CD16−), intermediate (CD14++ CD16+), and nonclassical (CD14+ CD16++) …

Human primary monocytes comprise a heterogeneous population that can be classified into
three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−) …

Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis
(RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but …

Human blood monocytes comprise at least 3 subpopulations that differ in phenotype and
function. Here, we present the first in-depth regulome analysis of human classical (CD14++ …

Background It has been widely accepted that monocytes are one of the central mediators
contributing to inflammaging. However, it remains unclear whether aged monocytes, similar …

Intestinal cell death is a defining feature of Crohn's disease (CD), a major form of
inflammatory bowel disease. The focus on this aspect of enteric inflammation has mainly …

Metabolic changes drive monocyte differentiation and fate. Although abnormal mitochondria
metabolism and innate immune responses participate in the pathogenesis of many …