After fifteen years of genome-wide association studies (GWAS) in Parkinson's disease (PD),
what have we learned? Addressing this question will help catalogue the progress made …

Simple Summary Constant exposure to endogenous and environmental factors induces
oxidative stress and DNA damage. Rare brain disorders caused by defects in DNA repair …

Parkinson's disease has a large heritable component and genome-wide association studies
have identified over 90 variants with disease-associated common variants, providing deeper …

Genome‑wide association studies (GWASs) have revealed numerous loci associated with
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …

The association between glucocerebrosidase, encoded by GBA, and Parkinson's disease
(PD) highlights the role of the lysosome in PD pathogenesis. Genome-wide association …

Given that improved imputation software and high-coverage whole genome sequence
(WGS)-based haplotype reference panels now enable inexpensive approximation of WGS …

Parkinson's disease (PD) guidelines lack clear criteria for genetic evaluation. We assessed
the yield and rationale of genetic testing for PD in a routine clinical setting on a multicenter …

The loss of dopaminergic neurons in the substantia nigra and the abnormal accumulation of
synuclein proteins and neurotransmitters in Lewy bodies constitute the primary symptoms of …

Parkinson's disease (PD) has a large heritable component and genome-wide association
studies to date have identified over 90 variants associated with PD, providing deeper …

In the field of Parkinson's disease (PD) research, the study of genomics has become
increasingly important, focusing on global and scalable approaches to leverage massive …