Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

When considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism
Spectrum Disorder (ASD) are considered to be among the most severe in term of …

While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …

Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …

BACE1 was discovered as the β-secretase for initiating the cleavage of amyloid precursor
protein (APP) at the β-secretase site, while its close homology BACE2 cleaves APP within …

Dexmedetomidine (DEX) is a highly selective agonist of α2-receptors with sedative,
anxiolytic, and analgesic properties. Neuroprotective effects of dexmedetomidine have been …

Synaptic plasticity alters the strength of information flow between presynaptic and
postsynaptic neurons and thus modifies the likelihood that action potentials in a presynaptic …

Studying key biological events within complex model systems relies on dynamic and
functional imaging at optimum spatial and temporal resolutions. Intravital correlative light …

Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical
component in the pathophysiology of schizophrenia. However, the arrival of the genome …

Abstract The Roman High-(RHA) and Low-(RLA) avoidance rat lines/strains were generated
through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way …