Glyphosate is the most widely used herbicide worldwide. It is a broad spectrum herbicide
and its agricultural uses increased considerably after the development of glyphosate …

The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …

The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …

The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …

In 2008 we published recommendations on chemicals that would be appropriate to evaluate
the sensitivity and specificity of new/modified mammalian cell genotoxicity tests, in particular …

The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

Aflatoxins are found as food contaminant and some of them demonstrate a carcinogenic
effect. The aflatoxins biosynthetic pathway involves 15 successive steps. The aim of this …

Bisphenol A (BPA) is one of the most widely used and versatile chemical compounds in
polymer additives and epoxy resins for manufacturing a range of products for human …

The conventional battery for genotoxicity testing is not well suited to assessing the large
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …

Abstract The Genetic Toxicology Technical Committee (GTTC) of the Health and
Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) …