The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …

The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Investigations of antibiotic resistance from an environmental prospective shed new light on a
problem that was traditionally confined to a subset of clinically relevant antibiotic‐resistant …

Aquatic ecosystems subjected to anthropogenic pressures are places of rapid evolution of
microbial communities and likely hotspots for selection and emergence of antibiotic resistant …

Soil is a large reservoir of microbial diversity and the majority of antimicrobial compounds
used today in human and veterinary health care have been isolated from soil …

The simplistic image of the bacterium as an isolated, planktonic, self-cloning automaton is
refuted. We now recognize bacteria as microorganisms of enormous diversity and …