Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Abstract Species of Scedosporium and Lomentospora are considered as emerging
opportunists, affecting immunosuppressed and otherwise debilitated patients, although …

The treatment of invasive fungal infections remains challenging and the emergence of new
fungal pathogens as well as the development of resistance to the main antifungal drugs …

Infections due to Aspergillus species are an acute threat to human health; members of the
Aspergillus section Fumigati are the most frequently occurring agents, but depending on the …

Fungal infections are becoming one of the main causes of morbidity and mortality in people
with weakened immune systems. Mycoses are becoming more common, despite greater …

Systemic fungal infections are associated with high mortality rates despite adequate
treatment. Moreover, acquired resistance to antifungals is increasing, which further …

Galleria mellonella larvae have become a widely accepted and utilised infection model due
to the functional homology displayed between their immune response to infection and that …

In the past decade, Galleria mellonella (wax moth) larvae have become widely used as a
non-mammalian infection model. However, the full potential of this infection model has yet to …

Aspergillus species contain pathogenic and opportunistic fungal pathogens which have the
potential to cause mycosis (invasive aspergillosis) in humans. The existing antifungal drugs …