Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux
Y Xia, F Xu, M Xiong, H Yang, W Lin, Y Xie, H Xi… - Pharmacological …, 2021 - Elsevier
Targeted therapies and immunotherapy have brought substantial benefits to patients with
melanoma. However, brain metastases remain the biggest threat to the survival and quality …
melanoma. However, brain metastases remain the biggest threat to the survival and quality …
[HTML][HTML] Repositioning antipsychotic fluphenazine hydrochloride for treating triple negative breast cancer with brain metastases and lung metastases
F Xu, Y Xia, Z Feng, W Lin, Q Xue, J Jiang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Triple negative breast cancer (TNBC) patients have a high risk of brain metastases. This
deadly disease represents a major challenge for successful treatment, in part because of the …
deadly disease represents a major challenge for successful treatment, in part because of the …
4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis
DS Bryan, M Stack, K Krysztofiak… - Proceedings of the …, 2020 - National Acad Sciences
Metastases are the cause of the vast majority of cancer deaths. In the metastatic process,
cells migrate to the vasculature, intravasate, extravasate, and establish metastatic colonies …
cells migrate to the vasculature, intravasate, extravasate, and establish metastatic colonies …
In vivo delivery and therapeutic effects of a microRNA on colorectal liver metastases
Multiple therapeutic agents are typically used in concert to effectively control metastatic
tumors. Recently, we described microRNAs that are associated with the oligometastatic …
tumors. Recently, we described microRNAs that are associated with the oligometastatic …
FOXM1-mediated activation of phospholipase D1 promotes lipid droplet accumulation and reduces ROS to support paclitaxel resistance in metastatic cancer cells
X Zhang, C Huang, Y Yuan, S Jin, J Zhao… - Free Radical Biology …, 2022 - Elsevier
Chemoresistance is a major challenge for the treatment of cancer with metastasis. We
investigated the mechanisms of lipid metabolites involved in drug resistance. Here …
investigated the mechanisms of lipid metabolites involved in drug resistance. Here …
Synergistic effect of a drug loaded electrospun patch and systemic chemotherapy in pancreatic cancer xenograft
E Jun, SC Kim, CM Lee, J Oh, S Lee, IK Shim - Scientific reports, 2017 - nature.com
Pancreatic cancer has a high rate of local recurrence and poor prognosis even with adjuvant
chemotherapy after curative resection. The aim of this study was to investigate if local drug …
chemotherapy after curative resection. The aim of this study was to investigate if local drug …
Combined use of tail vein metastasis assays and real-time in vivo imaging to quantify breast cancer metastatic colonization and burden in the lungs
JSA Warren, PJ Feustel, JM Lamar - JoVE (Journal of Visualized …, 2019 - jove.com
Metastasis is the main cause of cancer-related deaths and there are limited therapeutic
options for patients with metastatic disease. The identification and testing of novel …
options for patients with metastatic disease. The identification and testing of novel …
[PDF][PDF] Portal vein injection of colorectal cancer organoids to study the liver metastasis stroma
Hepatic metastasis of colorectal cancer (CRC) is a leading cause of cancer-related death.
Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment …
Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment …