The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …

Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we
demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2 …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

We have combined genetic and biochemical approaches to analyze the function of the RNA-
binding protein Nova-1, the paraneoplastic opsoclonus-myoclonus ataxia (POMA) antigen …

The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion
channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem …

Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord,
brainstem, and other regions of the mammalian central nervous system. In this minireview …

The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor
superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective …

Studies using molecular modeling, genetic engineering, neurophysiology/pharmacology,
and whole animals have advanced our understanding of where and how inhaled …