Current development of pyrazole–azole hybrids with anticancer potential

S Zhang, Y Ye, Q Zhang, Y Luo, ZC Wang… - Future Medicinal …, 2023 - Taylor & Francis
Chemotherapy is a critical treatment modality for cancer patients, but multidrug resistance
remains one of the major challenges in cancer therapy, creating an urgent need for the …

Unveiling the cutting-edge synthetic methods and multifaceted applications of bis (pyrazolyl) methanes: A comprehensive review of recent advances

P Teli, N Sahiba, S Agarwal - Synthetic Communications, 2023 - Taylor & Francis
Bis (pyrazolyl) methanes are basically the dimer of pyrazoles, attached with various linkers
such as aliphatic, aromatic or heterocyclic moieties. This scaffold has been studied for its …

Synthesis, In vitro and In silico Studies of Novel Bis‐triazolopyridopyrimidines from Curcumin Analogues as Potential Aromatase Agents

SM Gomha, AAAA El‐Sayed, MEA Zaki… - Chemistry & …, 2024 - Wiley Online Library
Breast cancer remains a major global health issue, particularly affecting women and
contributing significantly to mortality rates. Current treatments for estrogen receptor‐positive …

An ultrasound assisted, ionic liquid-molecular iodine synergy driven efficient green synthesis of pyrrolobenzodiazepine-triazole hybrids as potential anticancer agents

M Saquib, S Ahamad, MF Khan, MI Khan… - Frontiers in …, 2023 - frontiersin.org
Herein, we report an efficient and eco-friendly, ultrasound assisted synthetic strategy for the
construction of diversified pyrrolobenzodiazepine-triazole hybrids, which are potentially …

Natural product-inspired synthesis of coumarin–chalcone hybrids as potential anti-breast cancer agents

NA Alhakamy, M Saquib, Sanobar, MF Khan… - Frontiers in …, 2023 - frontiersin.org
Twelve novel neo-tanshinlactone–chalcone hybrid molecules were constructed through a
versatile methodology involving the Horner–Wadsworth–Emmons (HWE) olefination of 4 …

Visible-light promoted catalyst-free (VLCF) multi-component synthesis of spiro indolo-quinazolinone-pyrrolo[3,4-a]pyrrolizine hybrids: evaluation of in vitro anticancer …

S Iqbal, Farhanaz, Roohi, MR Zaheer… - Journal of …, 2024 - Taylor & Francis
A new and highly efficient visible-light-promoted catalyst free (VLCF) strategy for neat and
clean synthesis of spiro indolo-quinazolinone-pyrrolo [3, 4-a] pyrrolizine hybrids (6a–d) has …

Photocatalytic activity of Rose Bengal encapsulated in zeolitic imidazolate framework-8 (RB@ ZIF-8): an innovative approach for the one pot synthesis of highly …

M Goswami, P Paul, C Pandya, R Nongkhlaw… - Catalysis Science & …, 2024 - pubs.rsc.org
By exploring the photocatalytic activity of Rose Bengal (RB) encapsulated in zeolitic
imidazolate framework-8 (ZIF-8) under visible light irradiation, we developed a unique …

A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds

MS Nazir, M Ahmad, S Aslam, A Rafiq… - Drug Design …, 2024 - Taylor & Francis
Abstract The Coronavirus disease 2019 (COVID-19) pandemic is one of the most
considerable health problems across the world. Severe acute respiratory syndrome …

Visible light-promoted, catalyst-free synthesis of isoniazid azomethines: In vitro antioxidant activity, molecular docking, ADME and toxicity prediction

S Iqbal, MK Hussain, R Ansari, B Singh, I Akbar… - Journal of Molecular …, 2025 - Elsevier
Green synthesis of biologically active molecules is essential for environmental sustainability,
resource efficiency, reduced environmental impact, and compliance with regulations. It …

Visible Light‐Promoted Catalyst‐Free (VLCF) Scalable Synthesis of Novel Derivatives of Isoniazid and Maleimide

S Iqbal, MK Hussain, B Singh, MR Zaheer… - …, 2024 - Wiley Online Library
We have developed a Visible Light Promoted Catalyst‐Free (VLCF) approach to synthesize
novel conjugates of Isoniazid and Maleimide. This method involves the formation of an …