Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
All you need to know about sperm RNAs
J Santiago, JV Silva, J Howl… - Human Reproduction …, 2022 - academic.oup.com
BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …
is apparently incapable of transcription and translation. For many years, this dogma was …
Exosomal microRNAs in seminal plasma are markers of the origin of azoospermia and can predict the presence of sperm in testicular tissue
Abstract STUDY QUESTION Are exosomal microRNAs (miRNAs) in seminal plasma (SP)
useful as markers of the origin of azoospermia and the presence of sperm in the testis …
useful as markers of the origin of azoospermia and the presence of sperm in the testis …
Semen miRNAs contained in exosomes as non-invasive biomarkers for prostate cancer diagnosis
Although it is specific for prostatic tissue, serum prostate-specific antigen (PSA) screening
has resulted in an over-diagnosis of prostate cancer (PCa) and many unnecessary biopsies …
has resulted in an over-diagnosis of prostate cancer (PCa) and many unnecessary biopsies …
The role of miRNAs in male human reproduction: A systematic review
Background The presence of miRNAs in human reproductive tissue is intriguing and
suggests the possibility that these important regulatory molecules play a role in reproductive …
suggests the possibility that these important regulatory molecules play a role in reproductive …
Qualitative and quantitative assessment of sperm miRNAs identifies hsa-miR-9-3p, hsa-miR-30b-5p and hsa-miR-122-5p as potential biomarkers of male infertility and …
M Joshi, SW Andrabi, RK Yadav, SN Sankhwar… - Reproductive Biology …, 2022 - Springer
Background In contrast with the preceding stages of the germ cells, spermatozoa are
unusually rich in small non-coding RNAs in comparison to the coding RNAs. These small …
unusually rich in small non-coding RNAs in comparison to the coding RNAs. These small …
The roles of microRNAs in male infertility
MicroRNAs applications were vastly studied throughout the years, spanning from potential
cancer biomarkers to targeted therapies for various diseases. Out of these utilizations, this …
cancer biomarkers to targeted therapies for various diseases. Out of these utilizations, this …
Paternal epigenetics: mammalian sperm provide much more than DNA at fertilization
The spermatozoon is a highly differentiated cell with unique characteristics: it is mobile,
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …
thanks to its flagellum, and is very compact. The sperm cytoplasm is extremely reduced …
Using miRNAs as diagnostic biomarkers for male infertility: Opportunities and challenges
A Vashisht, GK Gahlay - Molecular Human Reproduction, 2020 - academic.oup.com
The non-coding genome has been extensively studied for its role in human development
and diseases. MicroRNAs (miRNAs) are small non-coding RNAs, which can regulate the …
and diseases. MicroRNAs (miRNAs) are small non-coding RNAs, which can regulate the …
Identification of ITPR1 gene as a novel target for hsa-miR-34b-5p in non-obstructive azoospermia: a Ca2+/apoptosis pathway cross-talk
Abstract MiR-34b-5p has been reported as a non-invasive diagnostic biomarker for infertility.
However, no gene targets regulating the mechanism of cation of this miRNA are known. In …
However, no gene targets regulating the mechanism of cation of this miRNA are known. In …