Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers

XJ Gao, K Ciura, Y Ma, A Mikolajczyk… - Advanced …, 2024 - Wiley Online Library
The pioneering work on liposomes in the 1960s and subsequent research in controlled drug
release systems significantly advances the development of nanocarriers (NCs) for drug …

Modulation of macrophages using nanoformulations with curcumin to treat inflammatory diseases: A concise review

H Sun, M Zhan, S Mignani, D Shcharbin, JP Majoral… - Pharmaceutics, 2022 - mdpi.com
Curcumin (Cur), a traditional Chinese medicine extracted from natural plant rhizomes, has
become a candidate drug for the treatment of diseases due to its anti-inflammatory …

Synthesis and characterization of folic acid-functionalized DPLA-co-PEG nanomicelles for the targeted delivery of letrozole

N Rostami, MM Gomari, M Abdouss… - ACS Applied Bio …, 2023 - ACS Publications
An effective treatment for hormone-dependent breast cancer is chemotherapy using
cytotoxic agents such as letrozole (LTZ). However, most anticancer drugs, including LTZ, are …

Phenyl boronic acid-PEG-stearic acid biomaterial-based and sialic acid targeted nanomicelles for colon cancer treatment

AK Jangid, R Solanki, M Jadav, S Bora, S Patel… - Colloids and Surfaces A …, 2023 - Elsevier
This study aims to develop and evaluate a sialic acid receptor-targeting biomaterial for an
effective delivery of usnic acid (UA). The novel biomaterial system is composed of three …

Amphiphilic phosphorous dendron micelles co-deliver microRNA inhibitor and doxorubicin for augmented triple negative breast cancer therapy

L Chen, M Zhan, J Li, L Cao, H Sun… - Journal of Materials …, 2023 - pubs.rsc.org
Combined chemo/gene therapy of cancer through different action mechanisms has been
emerging to enhance the therapeutic efficacy towards cancer, and still remains a …

Unsymmetrical Low-Generation Cationic Phosphorus Dendrimers as a Nonviral Vector to Deliver MicroRNA for Breast Cancer Therapy

Y Zou, S Shen, A Karpus, H Sun, R Laurent… - …, 2024 - ACS Publications
The development of nonviral dendritic polymers with a simple molecular backbone and
great gene delivery efficiency to effectively tackle cancer remains a great challenge …

Low-Generation Cationic Phosphorus Dendrimers: Novel Approach to Tackle Drug-Resistant S. aureus In Vitro and In Vivo

E Apartsin, A Akhir, G Kaul, D Saxena… - …, 2023 - ACS Publications
The incessant, global increase in antimicrobial resistance (AMR) is a very big challenge for
healthcare systems. AMR is predicted to grow at an alarming pace, with a dramatic increase …

The impact of PEG chain length on the in vivo tumor accumulation of self-assembled amphiphilic drug-PEG polymeric micelles

M Zheng, T Mei, C Deng, J Xin, O Aras, F An… - Colloids and Surfaces A …, 2024 - Elsevier
The integration of a drug and polyethylene glycol (PEG) into an amphiphilic polymer to form
self-assembled micelles with high drug loading for self-delivery to tumors is recently …

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

K Sztandera, JL Rodríguez-García, V Ceña - Pharmaceutics, 2024 - mdpi.com
Over the last few years, the development of nanotechnology has allowed for the synthesis of
many different nanostructures with controlled sizes, shapes, and chemical properties, with …

Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure

A Edr, D Wrobel, A Krupková, LC Št′ astná… - …, 2024 - ACS Publications
Here, we present a modular synthesis as well as physicochemical and biological evaluation
of a new series of amphiphilic dendrons carrying triphenylphosphonium groups at their …