Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

Intellectual curiosity has always been one of the major driving forces leading to new
advances in chemistry. At the onset of the 20th century, the fact that biaryls could be optically …

The advent of modern antibiotics contributed enormously to the dramatic extension of
human lifespan since their discovery by virtue of their lethal and selective action against …

Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for
over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used …

To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

Organomagnesium reagents occupy a central position in synthetic organic and
organometallic chemistry. Recently, the halogen–magnesium exchange has considerably …

Wenn man die Entwicklung der organischen Chemie betrachtet, kommt man schnell zu dem
Schluss, dass kein Reaktionstyp dieses Gebiet in vergleichbarer Weise geprägt hat wie die …

The accelerated appearance of drug-resistant bacteria poses an ever-growing threat to
modern medicine's capacity to fight infectious diseases. Gram-positive species such as …

Antibiotics are precious resources in the fight to combat bacterial infections caused by
pathogenic organisms. Vancomycin is one of the antibiotics of last resort in the treatment of …