Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

Sepsis is a lethal syndrome with a high incidence and a weighty economy burden. The
pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of …

Cardiac dysfunction is common in patients with severe sepsis and septic shock. Current
understanding of the underlying mechanisms responsible is rapidly evolving and future …

Mitochondria are an essential part of the cellular infrastructure, being the primary site for
high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly …

Recently, the definition of sepsis was concluded to be a life-threatening organ dysfunction
caused by a dysregulated host response to infection. Severe patients always present with …

Mitochondrial dysfunction is increasingly recognized as an accomplice in most of the
common human diseases including cancer, neurodegeneration, diabetes …

Dystrophin deficiency is the genetic basis for Duchenne muscular dystrophy (DMD), but the
cellular basis of progressive myofiber death in DMD is not fully understood. Using two …

Abstract Sepsis-induced cardiomyopathy (SIC), which is a common morbid condition, occurs
in patients with severe sepsis and septic shock. The clinical characterization of SIC has …

Sepsis is a dysregulated response to severe infection characterized by life-threatening
organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the …

Sepsis and multiple organ dysfunction syndrome (MODS) are major causes of morbidity and
mortality in the intensive care unit. Recently mitochondrial dysfunction has been proposed …