Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives
N Skarne, RCJ D'Souza, HM Palethorpe… - Acta Neuropathologica …, 2025 - Springer
Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor
prognosis and a dismal five-year survival rate. Despite significant knowledge gains in …
prognosis and a dismal five-year survival rate. Despite significant knowledge gains in …
Spatial assessment of stromal B cell aggregates predicts response to checkpoint inhibitors in unresectable melanoma
Quantitative assessment of multiplex immunofluorescence (mIF) data represents a powerful
tool for immunotherapy biomarker discovery in melanoma and other solid tumors. In addition …
tool for immunotherapy biomarker discovery in melanoma and other solid tumors. In addition …
[HTML][HTML] Harnessing Molecular Insights for Translational Impact: Highlights from the Special Issue Titled “New Insights in Translational Bioinformatics”
C Quek - International Journal of Molecular Sciences, 2025 - mdpi.com
The field of translational bioinformatics is rapidly evolving, driving the convergence of
molecular sciences and computational methods with their applications in industrial and …
molecular sciences and computational methods with their applications in industrial and …
Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus
Spatially mapping the transcriptome and proteome in the same tissue section can
significantly advance our understanding of heterogeneous cellular processes and connect …
significantly advance our understanding of heterogeneous cellular processes and connect …
scMODAL: A general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links
Recent advancements in single-cell technologies have enabled comprehensive
characterization of cellular states through transcriptomic, epigenomic, and proteomic …
characterization of cellular states through transcriptomic, epigenomic, and proteomic …
[HTML][HTML] Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided …
P Bhattacharya, A Linnenbach, AP South… - …, 2024 - pmc.ncbi.nlm.nih.gov
Immune checkpoint inhibition (ICI) has emerged as a critical treatment strategy for
squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of …
squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of …