Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

M Kasravi, A Ahmadi, A Babajani… - Biomaterials …, 2023 - spj.science.org
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …

The stiffness of living tissues and its implications for tissue engineering

CF Guimarães, L Gasperini, AP Marques… - Nature Reviews …, 2020 - nature.com
The past 20 years have witnessed ever-growing evidence that the mechanical properties of
biological tissues, from nanoscale to macroscale dimensions, are fundamental for cellular …

Tissue-engineered grafts from human decellularized extracellular matrices: a systematic review and future perspectives

A Porzionato, E Stocco, S Barbon, F Grandi… - International journal of …, 2018 - mdpi.com
Tissue engineering and regenerative medicine involve many different artificial and biologic
materials, frequently integrated in composite scaffolds, which can be repopulated with …

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

SD Sackett, DM Tremmel, F Ma, AK Feeney… - Scientific reports, 2018 - nature.com
Extracellular matrix (ECM) plays an important developmental role by regulating cell
behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained …

[HTML][HTML] Research progress in decellularized extracellular matrix-derived hydrogels

W Zhang, A Du, S Liu, M Lv, S Chen - Regenerative therapy, 2021 - Elsevier
Decellularized extracellular matrix (dECM) is widely used in regenerative medicine as a
scaffold material due to its unique biological activity and good biocompatibility. Hydrogel is a …

[HTML][HTML] Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal

M Tao, T Ao, X Mao, X Yan, R Javed, W Hou, Y Wang… - Bioactive materials, 2021 - Elsevier
Sterilization is the process of killing all microorganisms, while disinfection is the process of
killing or removing all kinds of pathogenic microorganisms except bacterial spores …

Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes

A Citro, A Neroni, C Pignatelli, F Campo… - Nature …, 2023 - nature.com
Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However,
the shortage of organ donors and an unsatisfactory engraftment limit its application to a …

Strategies based on organ decellularization and recellularization

KH Hillebrandt, H Everwien, N Haep… - Transplant …, 2019 - Wiley Online Library
Transplantation is the only curative treatment option available for patients suffering from end‐
stage organ failure, improving their quality of life and long‐term survival. However, because …

ECM in differentiation: a review of matrix structure, composition and mechanical properties

A Padhi, AS Nain - Annals of biomedical engineering, 2020 - Springer
Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate
into other cell types is a promising avenue in regenerative medicine. Stem cell niche not …

Polymer hydrogels to guide organotypic and organoid cultures

V Magno, A Meinhardt, C Werner - Advanced Functional …, 2020 - Wiley Online Library
Human organotypic and organoid cultures provide increasingly life‐like models of
tissue/organ development and disease, enable more realistic drug screening, and may …