In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols
In vitro-in vivo correlation is the establishment of a predictive relationship between in vitro
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
Bioequivalence assessment of pharmaceutical aerosol products through IVIVC
D Sandell - Advanced Drug Delivery Reviews, 2021 - Elsevier
Many pharmaceutical developers of generic orally inhaled products (OIPs) are facing
significant issues in passing the regulatory requirement to show pharmacokinetic (PK) …
significant issues in passing the regulatory requirement to show pharmacokinetic (PK) …
Mucus, airway and plume temperature effects on pMDI-drug delivery in a mouth-throat airway: Experimental and numerical studies
M Jahed, J Kozinski, L Pakzad - Journal of Aerosol Science, 2024 - Elsevier
Effective pulmonary drug delivery through pressurized-metered dose inhalers (pMDIs)
depends on accurately targeting pharmaceutical aerosols to specific lung areas. Achieving …
depends on accurately targeting pharmaceutical aerosols to specific lung areas. Achieving …
Computational investigation of particle penetration and deposition pattern in a realistic respiratory tract model from different types of dry powder inhalers
The aim of this study was to evaluate the device performance of a new design by comparing
with a typical commercial DPI. Computational fluid dynamics (CFD) coupled with the discrete …
with a typical commercial DPI. Computational fluid dynamics (CFD) coupled with the discrete …
Can pharmacokinetic studies assess the pulmonary fate of dry powder inhaler formulations of fluticasone propionate?
In the context of streamlining generic approval, this study assessed whether
pharmacokinetics (PK) could elucidate the pulmonary fate of orally inhaled drug products …
pharmacokinetics (PK) could elucidate the pulmonary fate of orally inhaled drug products …
Simulating the effect of individual upper airway anatomical features on drug deposition
This study aims to systematically isolate different anatomical features of the human pharynx
with the goal to investigate their independent influence on airflow dynamics and particle …
with the goal to investigate their independent influence on airflow dynamics and particle …
Targeting of inhaled therapeutics to the small airways: Nanoleucine carrier formulations
Current dry powder formulations for inhalation deposit a large fraction of their emitted dose
in the upper respiratory tract where they contribute to off-target adverse effects and variability …
in the upper respiratory tract where they contribute to off-target adverse effects and variability …
Numerical study on the deposition distribution and mechanism of inhaled drug particles in various regions of the realistic inhaler-airway model
Inhaled drug delivery is widely used in the treatment of respiratory diseases. Understanding
the deposition mechanisms of dry powder inhalers (DPIs) in different regions of the airway is …
the deposition mechanisms of dry powder inhalers (DPIs) in different regions of the airway is …
Initial development of an air-jet dry powder inhaler for rapid delivery of pharmaceutical aerosols to infants
Background: Positive-pressure dry powder inhalers (DPIs) have recently been developed
that in combination with highly dispersible spray-dried powder formulations can achieve …
that in combination with highly dispersible spray-dried powder formulations can achieve …
Droplet deposition dynamics in a realistic three-dimensionally printed human upper airway: An in vitro study
J Huang, Y Zhang, X Chen, Y Cai, Y Zhang, Z Jia - Physics of Fluids, 2024 - pubs.aip.org
This study presents the first known successful in vitro measurement of both deposition
fractions (DFs) and spatial deposition patterns of nebulized droplets in a realistic human …
fractions (DFs) and spatial deposition patterns of nebulized droplets in a realistic human …