Poly (ADP-ribose) polymerase inhibitors (PARPi) have significantly changed the treatment
landscape for tumours harbouring defects in genes involved in homologous repair (HR) …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Following nearly two decades of development, significant advancements have been
achieved in PROTAC technology. As of the end of 2022, more than 20 drugs have entered …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors show potent antiproliferative
activity in treatment with triple-negative breast cancer (TNBC) when combined with …

Ligase IV is a key enzyme involved during DNA double-strand breaks (DSBs) repair through
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …

Background: One of the most significant challenges impeding cancer treatment effectiveness
is drug resistance. Combining evolutionary understanding with drug resistance can pave the …

Objectives Human papillomavirus (HPV) positive head and neck squamous cell carcinoma
(HNSCC) showed a considerably better prognosis with greater cisplatin sensitivity …

The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD),
a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are …

Hyperthermia, the raising of tumor temperature (≥ 39° C), holds great promise as an
adjuvant treatment for cancer therapy. This review focuses on 2 key aspects of hyperthermia …

DNA double-strand breaks (DSBs) are cytotoxic lesions that compromise genomic integrity
and trigger cell death. Homologous recombination (HR) is a major pathway for repairing …