In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

Until recently, the transport of folates into cells and across epithelia has been interpreted
primarily within the context of two transporters with high affinity and specificity for folates, the …

This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates …

The properties of intestinal folate absorption were documented decades ago. However, it
was only recently that the proton-coupled folate transporter (PCFT) was identified and its …

The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and
thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers …

This chapter focuses on the biology of the major facilitative membrane folate transporters,
the reduced folate carrier (RFC), and the proton-coupled folate transporter (PCFT). Folates …

ABCG2 is an efflux transporter conferring multidrug resistance (MDR) on cancer cells.
However, the initial molecular events leading to its up-regulation in MDR tumor cells are …

Folic acid (FA) is well known to prevent neural tube defects (NTDs), but we do not know why
many human NTD cases still remain refractory to FA supplementation. Here, we investigate …

Simple Summary New therapies are urgently needed for ovarian cancer, the most lethal
malignancy in women. To identify new approaches for targeting ovarian cancer, metabolic …

Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of …