Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

The endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) form major intracellular
Ca 2+ stores. Ryanodine receptors (RyRs) are large tetrameric ion channels in the SR and …

Abstract Ryanodine Receptors (RyRs) are massive channels that release Ca2+ from the
endoplasmic and sarcoplasmic reticulum. Hundreds of mutations are linked to malignant …

Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of
neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) …

The two major calcium (Ca 2+) release channels on the sarco/endoplasmic reticulum
(SR/ER) are inositol 1, 4, 5-trisphosphate and ryanodine receptors (IP 3 Rs and RyRs). They …

Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is
known to bind and modulate more than a 100 targets. Recently, several disease-associated …

The intracellular Ca 2+ sensor calmodulin (CaM) regulates the cardiac Ca 2+ release
channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause arrhythmias such as …

Abstract The calcium (Ca 2+) ion is a universal signalling messenger which plays vital
physiological roles in all eukaryotes. To decode highly regulated intracellular Ca 2+ signals …

Key points Mutations in the calmodulin protein (CaM) are associated with arrhythmia
syndromes. This study focuses on understanding the structural characteristics of CaM …