An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system
The immune system comprises a complex yet tightly regulated network of cells and
molecules that play a critical role in protecting the body from infection and disease. The …
molecules that play a critical role in protecting the body from infection and disease. The …
Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells
M Malik, WJ de Leeuw, MA Aslam… - bioRxiv, 2025 - biorxiv.org
The histone methyltransferase DOT1L is emerging as a central epigenetic regulator in
immune cells. Loss of DOT1L during development of CD8 T cells in vivo leads to gain of …
immune cells. Loss of DOT1L during development of CD8 T cells in vivo leads to gain of …