Purpose We previously identified three genes, HOXB13, IL17BR and CHDH, and the
HOXB13: IL17BR ratio index in particular, that strongly predicted clinical outcome in breast …

Dlx homeobox transcription factors regulate epidermal, neural and osteogenic cellular
differentiation. Here, we demonstrate the central role of Dlx3 as a crucial transcriptional …

Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers
distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained …

Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-
silencing pathways It exerts a pivotal role in microRNA maturation and activity and can …

HOX genes are highly conserved transcription factors that determine the identity of cells and
tissues along the anterior–posterior body axis in developing embryos. Aberrations in HOX …

Malignant melanoma is a cancer that arises from melanocyte cells in a complex but well-
studied process, and which can only be successfully treated prior to metastasis as it is highly …

With advances in screening, the incidence of detection of premalignant breast lesions has
increased in recent decades; however, treatment options remain limited to surveillance or …

The homeobox (HOX) genes, a class of transcription factors, are known to promote
embryonic development and induce tumor formation. To date, the HOXA and HOXB gene …

Recently, the homeobox (HOX) gene family has been reported as a factor in tumorigenesis.
In the human genome, the HOX gene family contains 4 clusters with 39 genes and multiple …

Purpose: HOX genes are vital for all aspects of mammalian growth and differentiation, and
recent data have shown that their deregulated expression is related to carcinogenesis. To …