The cyanotoxin-microcystins: current overview

RP Rastogi, RP Sinha, A Incharoensakdi - Reviews in Environmental …, 2014 - Springer
The monocyclic heptapeptides microcystins (MCs), are a group of hepatotoxins, produced
worldwide by some bloom-forming cyanobacterial species/strains both in marine and …

New insights on the mode of action of microcystins in animal cells-a review

E Valério, V Vasconcelos… - Mini reviews in medicinal …, 2016 - ingentaconnect.com
Microcystins (MCs) are the most commonly occurring hepatotoxins produced by
cyanobacteria. The inhibition of PP2A is widely assumed as the principal mechanism of …

Astragalus membranaceus polysaccharides modulate growth, hemato-biochemical indices, hepatic antioxidants, and expression of HSP70 and apoptosis-related …

MR Farag, M Alagawany, SR Khalil… - Fish & Shellfish …, 2021 - Elsevier
A 60-day experiment was performed to assess the efficacy of dietary Astragalus
membranaceus polysaccharides (ASP) in attenuation of sub-lethal thallium (Tl) toxicity in …

Behavioral, physiological, and inflammatory responses of Oreochromis niloticus fish exposed to thallium and/or supplementation with Astragalus membranaceus …

MR Farag, YA Attia, LS Al Solami, F Bovera, A Nizza… - Aquaculture, 2022 - Elsevier
The present study was conducted to investigate the behavioral, biochemical, and molecular
responses of Oreochromis niloticus fish exposed to sublethal concentration of thallium (T1; …

Bioaccumulation of microcystin and its oxidative stress in the apple (Malus pumila)

J Chen, J Dai, H Zhang, C Wang, G Zhou, Z Han, Z Liu - Ecotoxicology, 2010 - Springer
The bioaccumulation and harmful effects of microcystins (MCs) and the activity of peroxidase
(POD) and superoxide dismutase (SOD) were examined in the apple (Malus pumila) …

Temperature-dependent viral replication and antiviral apoptotic response in viral haemorrhagic septicaemia virus (VHSV)-infected olive flounder (Paralichthys …

S Avunje, WS Kim, MJ Oh, I Choi, SJ Jung - Fish & Shellfish Immunology, 2012 - Elsevier
The olive flounder (Paralichthys olivaceus) shows a high rate of mortality to viral
haemorrhagic septicaemia virus (VHSV) in the winter and spring but has zero mortality over …

Microcystin-leucine arginine blocks vasculogenesis and angiogenesis through impairing cytoskeleton and impeding endothelial cell migration by downregulating …

Q Wang, G Chen, Q Zhang, M Wang, G Wang… - … Science and Pollution …, 2021 - Springer
The main characteristic of eutrophication is cyanobacteria harmful algae blooms. Microcystin-
leucine arginine (MC-LR) is considered to be the most toxic and most commonly secondary …

The effect and mechanism of combined exposure of MC-LR and NaNO2 on liver lipid metabolism

J Yang, Z Zhang, X Du, Y Wang, R Meng, K Ge… - Environmental …, 2024 - Elsevier
Abstract Microcystin-LR (MC-LR) and sodium nitrite (NaNO 2) co-exist in the environment
and are hepatotoxic. The liver has the function of lipid metabolism, but the impacts and …

Expression profiling in vivo demonstrates rapid changes in liver microRNA levels of whitefish (Coregonus lavaretus) following microcystin-LR exposure

P Brzuzan, M Woźny, L Wolińska, A Piasecka - Aquatic toxicology, 2012 - Elsevier
At present, little is known about the role of miRNAs in liver response of fish to the
cyanobacterial hepatotoxin microcystin-LR (MC-LR) treatment, despite the fact that the …

Microcystin-LR induces apoptosis via NF-κB/iNOS pathway in INS-1 cells

Y Ji, G Lu, G Chen, B Huang, X Zhang, K Shen… - International journal of …, 2011 - mdpi.com
Cyanobacterial toxins, especially the microcystins, are found in eutrophied waters
throughout the world, and their potential to impact on human and animal health is a cause …