Epigenetics in cancer therapy and nanomedicine

A Roberti, AF Valdes, R Torrecillas, MF Fraga… - Clinical …, 2019 - Springer
The emergence of nanotechnology applied to medicine has revolutionized the treatment of
human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs …

The impact of epigenetics on cardiovascular disease

D Prasher, SC Greenway… - Biochemistry and Cell …, 2020 - cdnsciencepub.com
Mortality and morbidity from cardiovascular diseases (CVDs) represents a huge burden to
society. It is recognized that environmental factors and individual lifestyles play important …

[HTML][HTML] Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy

C Griñán-Ferré, A Bellver-Sanchis, A Guerrero… - Pharmacological …, 2024 - Elsevier
About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …

An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression

AA Khan, X Liu, X Yan, M Tahir, S Ali… - Cancer and metastasis …, 2021 - Springer
Pancreatic cancer (PC) is assumed to be an intimidating and deadly malignancy due to
being the leading cause of cancer-led mortality, predominantly affecting males of older age …

Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

WO Castillo-Ordoñez, N Cajas-Salazar… - Neural regeneration …, 2024 - journals.lww.com
Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

Role of epigenetics in carcinogenesis: recent advancements in anticancer therapy

S Hussain, S Tulsyan, SA Dar, S Sisodiya… - Seminars in cancer …, 2022 - Elsevier
The role of epigenetics in the etiology of cancer progression is being emphasized for the
past two decades to check the impact of chromatin modifiers and remodelers. Histone …

[HTML][HTML] Enhancer of zeste homologue 2 inhibition attenuates TGF-β dependent hepatic stellate cell activation and liver fibrosis

R Martin-Mateos, TM De Assuncao, JP Arab… - Cellular and Molecular …, 2019 - Elsevier
Background & Aims Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts
is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and …

Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysis

Z Ahmed - Progress in molecular biology and translational …, 2022 - Elsevier
Precision medicine is driven by the paradigm shift of empowering clinicians to predict the
most appropriate course of action for patients with complex diseases and to improve routine …

Getting personal with epigenetics: towards individual-specific epigenomic imputation with machine learning

A Hawkins-Hooker, G Visonà, T Narendra… - Nature …, 2023 - nature.com
Epigenetic modifications are dynamic mechanisms involved in the regulation of gene
expression. Unlike the DNA sequence, epigenetic patterns vary not only between …

Multi-omics strategies for personalized and predictive medicine: past, current, and future translational opportunities

Z Ahmed - Emerging topics in life sciences, 2022 - portlandpress.com
Precision medicine is driven by the paradigm shift of empowering clinicians to predict the
most appropriate course of action for patients with complex diseases and improve routine …