Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

The compartmentalization of eukaryotic cells, which is essential for their viability and
functions, is ensured by single or double bilayer membranes that separate the cell from the …

The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise
intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

Bone is a complex organ maintained by three main cell types: osteoblasts, osteoclasts, and
osteocytes. During bone formation, osteoblasts deposit a mineralized organic matrix …

Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to
repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that …

Bilayered membranes separate cells from their surroundings and form boundaries between
intracellular organelles and the cytosol. Gated transport of solutes across membranes …

Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …