Chemotherapy and ovarian ablation both independently improve survival in premenopausal
women with hormone-sensitive breast cancer. Amenorrhea is a well-recognized occurrence …

Cardiac toxicity is an uncommon but potentially serious complication of high-dose (HD)
chemotherapy and little is known about incidence, severity and underlying mechanisms. We …

Objectives: The purpose of this study was to evaluate the clinical relevance of anthracycline-
induced cardiomyopathy (AC-CMP) and its response to heart failure (HF) therapy …

Background—An increase in troponin I soon after high-dose chemotherapy (HDC) is a
strong predictor of poor cardiological outcome in cancer patients. This finding has important …

Chemotherapy is associated with cognitive impairment in a subgroup of breast cancer
survivors, but the neural circuitry underlying this side effect is largely unknown. Moreover …

Background Amplification of the human epidermal growth factor receptor type 2 (HER2, also
called HER2/neu) gene and overexpression of its product in breast-cancer cells may be …

The alkylating agents are antitumor drugs that act through the covalent binding of alkyl
groups to cellular molecules. This binding is mediated by reactive intermediates formed from …

Some breast cancer survivors experience cognitive decline following chemotherapy. We
prospectively examined changes in cognitive performance among high-risk breast cancer …

Background Breast cancer cells deficient for BRCA1 are hypersensitive to agents inducing
DNA double-strand breaks (DSB), such as bifunctional alkylators and platinum agents …

Inflammatory breast cancer (IBC) is a rare but very aggressive form of breast cancer. Its
definition is based on clinical criteria, but a molecular definition could be useful when data …