Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can
covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

As a kind of serious, potentially sight-threatening corneal infections with poor prognosis,
fungal keratitis can bring a heavy economic burden to patients and seriously affect the …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule,
intracellularly and extracellularly, and conjugated to target proteins. Studies in mice have …

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …

Cancer stem cells (CSC) are thought to play a major role in the development and metastatic
progression of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors …

Abstract p53 plays a pivotal role in tumour suppression under stresses, such as DNA
damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the …