Endothelial cells (ECs) develop organ-specific gene expression and function in response to
signals from the surrounding tissue. In turn, ECs can affect organ development and …

The past decades have seen markedly improved survival of increasingly immature preterm
infants, yet major health complications persist. This is particularly true for bronchopulmonary …

Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a
lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 …

Abnormal lung development is the main cause of morbidity and mortality in neonates with
congenital diaphragmatic hernia (CDH), a common birth defect (1: 2,500) of largely …

Rationale: Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of
the diaphragm and lung hypoplasia. The pathophysiology of lung defects in CDH is poorly …

Objective Increased inflammation and cytokine levels are considered risk factors and
promoters of preterm birth (PTB). However, the regulatory mechanism of pregnancy-related …

Introduction Preterm birth, defined as birth before 37 weeks of gestation, is the leading
cause of death of children under the age of five years worldwide. Globally there has been no …

Up to 40% of preterm births are associated with histological chorioamnionitis (HCA), which
leads to elevated levels of pro-inflammatory mediators and microbial products in the …

Skin exposure to high-dose irradiation, as commonly practiced in radiotherapy, affects the
different skin layers, causing dry and wet desquamation, hyperkeratosis fibrosis, hard to heal …

Histological evidence of tissue injury is considered the most relevant defining feature of
experimental acute lung injury (ALI). In humans, ALI/acute respiratory distress syndrome …