Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

The recognition of potentially harmful food components by the gustatory system is important
for survival and well-being of vertebrates. The plethora of structurally diverse bitter …

Bitter taste receptors (T2Rs) belong to the super family of G protein-coupled receptors
(GPCRs). There are 25 T2Rs expressed in humans, and these interact with a large and …

Taste sensitivity to PROP varies greatly among individuals and is associated with
polymorphisms in the bitter receptor gene TAS2R38, and with differences in fungiform …

We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus mutates,
finding effective drugs becomes more challenging. In this study, we use ultrasensitive …

These recent studies identify a role for T2R38 in sinonasal innate immunity and chronic
rhinosinusitis. Clinical implications include the potential development of T2R38-directed …

G protein-coupled receptors (GPCRs) are seven transmembrane (TM) proteins that play a
key role in human physiology. The GPCR superfamily comprises about 800 members …