Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

Oligodendrocytes (OLs) are a major type of glial cells in the central nervous system that
generate multiple myelin sheaths to wrap axons. Myelin ensures fast and efficient …

Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate
neurons following forced expression of neurogenic transcription factors, thus opening new …

Functional gene analysis requires the possibility of overexpression, as well as
downregulation of one, or ideally several, potentially interacting genes. Lentiviral vectors are …

We have developed a four-part protocol to differentiate human embryonic stem cells
(hESCs) to oligodendrocyte progenitor cells (OPCs) according to developmental principles …

Abstract Specification of distinct cell types from human embryonic stem cells (hESCs) is key
to the potential application of these naïve pluripotent cells in regenerative medicine …

The mechanisms underlying the regulation of neural stem cell (NSC) renewal and
maintenance of their multipotency are still not completely understood. Self-renewal of stem …

Rationale: Demyelination is a major component of white matter injury, characterized by
oligodendrocyte (OL) death and myelin sheath loss, which result in memory loss and …

Human embryonic stem cells (hESCs) offer a platform to bridge what we have learned from
animal studies to human biology. Using oligodendrocyte differentiation as a model system …

A fundamental feature of central nervous system development is that neurons are generated
before glia. In the embryonic spinal cord, for example, a group of neuroepithelial stem cells …