Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry

D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

Immunological biomarkers of tuberculosis

G Walzl, K Ronacher, W Hanekom, TJ Scriba… - Nature Reviews …, 2011 - nature.com
Currently there are no sufficiently validated biomarkers to aid the evaluation of new
tuberculosis vaccine candidates, the improvement of tuberculosis diagnostics or the …

Recent and potential developments of biofluid analyses in metabolomics

A Zhang, H Sun, P Wang, Y Han, X Wang - Journal of proteomics, 2012 - Elsevier
Metabolomics, one of the 'omic'sciences in systems biology, is the global assessment and
validation of endogenous small-molecule metabolites within a biologic system. Analysis of …

Serum metabolomics as a novel diagnostic approach for disease: a systematic review

A Zhang, H Sun, X Wang - Analytical and bioanalytical chemistry, 2012 - Springer
Metabolomics is a promising “omics” field in systems biology; its objective is comprehensive
analysis of low-molecular-weight endogenous metabolites in a biological sample. It could …

Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies

G Theodoridis, HG Gika… - Mass spectrometry reviews, 2011 - Wiley Online Library
Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …

Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium

S Altmäe, FJ Esteban, A Stavreus-Evers… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND 'Omics' high-throughput analyses, including genomics, epigenomics,
transcriptomics, proteomics and metabolomics, are widely applied in human endometrial …

The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses

NJ Serkova, TJ Standiford… - American journal of …, 2011 - atsjournals.org
Metabolomics, a science of systems biology, is the global assessment of endogenous
metabolites within a biologic system and represents a “snapshot” reading of gene function …

Metabolomics and its application to acute lung diseases

KA Stringer, RT McKay, A Karnovsky… - Frontiers in …, 2016 - frontiersin.org
Metabolomics is a rapidly expanding field of systems biology that is gaining significant
attention in many areas of biomedical research. Also known as metabonomics, it comprises …

Metabolite and peptide levels in plasma and CSF differentiating healthy controls from patients with newly diagnosed Parkinson's disease

M Trupp, P Jonsson, A Öhrfelt… - Journal of …, 2014 - content.iospress.com
Background: Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative
disease for which there is no effective disease modifying treatment. A critical requirement for …

Recent advances of metabolomics in plant biotechnology

Y Okazaki, K Saito - Plant biotechnology reports, 2012 - Springer
Biotechnology, including genetic modification, is a very important approach to regulate the
production of particular metabolites in plants to improve their adaptation to environmental …