Antimicrobial Bacillus: Metabolites and Their Mode of Action

C Tran, IE Cock, X Chen, Y Feng - Antibiotics, 2022 - mdpi.com
The agricultural industry utilizes antibiotic growth promoters to promote livestock growth and
health. However, the World Health Organization has raised concerns over the ongoing …

Antimicrobial peptides as anti-infective agents in pre-post-antibiotic era?

T Rončević, J Puizina, A Tossi - International journal of molecular …, 2019 - mdpi.com
Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …

Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids

F Grein, A Müller, KM Scherer, X Liu, KC Ludwig… - Nature …, 2020 - nature.com
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …

Activity of specialized biomolecules against gram-positive and gram-negative bacteria

TD Tavares, JC Antunes, J Padrão, AI Ribeiro, A Zille… - Antibiotics, 2020 - mdpi.com
The increased resistance of bacteria against conventional pharmaceutical solutions, the
antibiotics, has raised serious health concerns. This has stimulated interest in the …

Targeting a cell wall biosynthesis hot spot

A Müller, A Klöckner, T Schneider - Natural product reports, 2017 - pubs.rsc.org
Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very
effective target for antibiotic intervention, and numerous natural product inhibitors have been …

Molecular Modeling and Simulation of the Peptidoglycan Layer of Gram-Positive Bacteria Staphylococcus aureus

R Pokhrel, R Shakya, P Baral… - Journal of Chemical …, 2022 - ACS Publications
The peptidoglycan (PG) layer is a vital component of the bacterial cell wall that protects the
cell from rupturing due to internal pressure. Its ubiquity across the bacterial kingdom but not …

Biomembranes in atomistic and coarse-grained simulations

K Pluhackova, RA Böckmann - Journal of physics: condensed …, 2015 - iopscience.iop.org
The architecture of biological membranes is tightly coupled to the localization, organization,
and function of membrane proteins. The organelle-specific distribution of lipids allows for the …

Lipid transport across bacterial membranes

SI Giacometti, MR MacRae… - Annual Review of …, 2022 - annualreviews.org
The movement of lipids within and between membranes in bacteria is essential for building
and maintaining the bacterial cell envelope. Moving lipids to their final destination is often …

The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa

JF Fisher, S Mobashery - Bioorganic chemistry, 2014 - Elsevier
The peptidoglycan is the structural polymer of the bacterial cell envelope. In contrast to an
expectation of a structural stasis for this polymer, during the growth of the Gram-negative …

Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by …

A Sikder, AK Pearce, CMS Kumar, RK O'Reilly - Materials Horizons, 2023 - pubs.rsc.org
With the increased prevalence of antibiotic-resistant infections, there is an urgent need to
develop novel antibacterial materials. In addition, gaining a complete understanding of the …