Resistance to antibiotics is one of the main current threats to human health and every year multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …
F Grein, A Müller, KM Scherer, X Liu, KC Ludwig… - Nature …, 2020 - nature.com
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram- positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …
The increased resistance of bacteria against conventional pharmaceutical solutions, the antibiotics, has raised serious health concerns. This has stimulated interest in the …
A Müller, A Klöckner, T Schneider - Natural product reports, 2017 - pubs.rsc.org
Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been …
R Pokhrel, R Shakya, P Baral… - Journal of Chemical …, 2022 - ACS Publications
The peptidoglycan (PG) layer is a vital component of the bacterial cell wall that protects the cell from rupturing due to internal pressure. Its ubiquity across the bacterial kingdom but not …
The architecture of biological membranes is tightly coupled to the localization, organization, and function of membrane proteins. The organelle-specific distribution of lipids allows for the …
SI Giacometti, MR MacRae… - Annual Review of …, 2022 - annualreviews.org
The movement of lipids within and between membranes in bacteria is essential for building and maintaining the bacterial cell envelope. Moving lipids to their final destination is often …
JF Fisher, S Mobashery - Bioorganic chemistry, 2014 - Elsevier
The peptidoglycan is the structural polymer of the bacterial cell envelope. In contrast to an expectation of a structural stasis for this polymer, during the growth of the Gram-negative …
With the increased prevalence of antibiotic-resistant infections, there is an urgent need to develop novel antibacterial materials. In addition, gaining a complete understanding of the …