Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard
clinical treatment includes chemotherapy, surgical therapy, and radiation therapy …

A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Bone diseases include a wide group of skeletal-related disorders that cause mobility
limitations and mortality. In some cases, eg, in osteosarcoma (OS) and metastatic bone …

For effective treatment of infected bone, it is essential to use local drug delivery systems with
the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk …

In this review, the most valuable opportunities offered by mesoporous silica nanoparticles in
the field of development of nanodevices for bionanotechnology applications are reviewed …

The development of stimuli-responsive nanomedicines with tunable cargo release is
gathering an increased applicability in bone regeneration and precision biomedicine. Yet …

As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal
(MSK) disorders is gradually increasing with each passing year, posing a serious threat to …

The systemic administration of drugs to treat bone diseases is often associated with poor
uptake of the drug in the targeted tissue, potential systemic toxicity and suboptimal efficacy …