Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

Idiopathic pulmonary fibrosis (IPF): an overview

SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

Syndrome of combined pulmonary fibrosis and emphysema: an official ATS/ERS/JRS/ALAT research statement

V Cottin, M Selman, Y Inoue, AW Wong… - American journal of …, 2022 - atsjournals.org
Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …

An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial …

WD Travis, U Costabel, DM Hansell… - American journal of …, 2013 - atsjournals.org
Background: In 2002 the American Thoracic Society/European Respiratory Society
(ATS/ERS) classification of idiopathic interstitial pneumonias (IIPs) defined seven specific …

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

RJ Allen, J Porte, R Braybrooke, C Flores… - The Lancet respiratory …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a …

Idiopathic pulmonary fibrosis

TE King, A Pardo, M Selman - The Lancet, 2011 - thelancet.com
Idiopathic pulmonary fibrosis is a devastating, age-related lung disease of unknown cause
that has few treatment options. This disease was once thought to be a chronic inflammatory …

[HTML][HTML] Lung cancer is also a hereditary disease

PR Benusiglio, V Fallet, M Sanchis-Borja… - European …, 2021 - Eur Respiratory Soc
Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …

Epidemiology of idiopathic pulmonary fibrosis

B Ley, HR Collard - Clinical epidemiology, 2013 - Taylor & Francis
Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs
in adults and has a poor prognosis. Its epidemiology has been difficult to study because of …

Animal models of fibrotic lung disease

B B. Moore, WE Lawson, TD Oury… - American journal of …, 2013 - atsjournals.org
Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure,
as a result of genetic defects, and after trauma or acute lung injury leading to …