Pubertal development and regulation
Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …
Child health, developmental plasticity, and epigenetic programming
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …
survival and reproductive success to the organism under changing environments …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants
BL Pierce, H Ahsan… - International journal of …, 2011 - academic.oup.com
Abstract Background Mendelian Randomization (MR) studies assess the causality of an
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
FR Day, DJ Thompson, H Helgason, DI Chasman… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …
Estrogen effects on the mammary gland in early and late life and breast cancer risk
A woman has an increased risk of breast cancer if her lifelong estrogen exposure is
increased due to an early menarche, a late menopause, and/or an absence of childbearing …
increased due to an early menarche, a late menopause, and/or an absence of childbearing …
The role of miRNAs in regulating gene expression networks
AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …
species, expressed across cell types, and active against a large proportion of the …
Detection of human adaptation during the past 2000 years
Detection of recent natural selection is a challenging problem in population genetics. Here
we introduce the singleton density score (SDS), a method to infer very recent changes in …
we introduce the singleton density score (SDS), a method to infer very recent changes in …
[HTML][HTML] Lin28 enhances tissue repair by reprogramming cellular metabolism
Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue
repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed …
repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed …
Delayed puberty
MR Palmert, L Dunkel - New England Journal of Medicine, 2012 - Mass Medical Soc
Key Clinical Points Delayed Puberty Delayed puberty is diagnosed when there is no
testicular enlargement in boys or breast development in girls at an age that is 2 to 2.5 SD …
testicular enlargement in boys or breast development in girls at an age that is 2 to 2.5 SD …