Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

In the late 19th century, a number of investigators were working on perfecting isolated heart
model, but it was Oscar Langendorff who, in 1895, pioneered the isolated perfused …

ABSTRACT The Lambeth Conventions are guidelines intended to be of practical value in
the investigation of arrhythmias induced by ischaemia, infarction, and reperfusion. They …

The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Arrhythmia scores have been used in recent years to facilitate the analysis of arrhythmias,
particularly in relation to regional myocardial ischaemia. The recent Lambeth Conventions …

The isolated heart is deservedly one of the most popular experimental models in
cardiovascular research, both in terms of cost and the quality and quantity of data it provides …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …

The human heart contains both β 1 and β-2-adrenoceptors; both mediated positive inotropic
and chronotropic effects. In chronic heart failure, β-adrenoceptor number is reduced …

Experimental studies examining the effects of regular exercise on cardiac responses to
ischemia and reperfusion (I/R) are limited. Therefore, these experiments examined the …