This paper is the outcome of the fourth UC Davis Systems Approach to Understanding
Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a biannual event …

Fatty acid infiltration of the myocardium, acquired in metabolic disorders (obesity, type-2
diabetes, insulin resistance, and hyperglycemia) is critically associated with the …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically
excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully …

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-
syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life …

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

Impaired protein stability or trafficking underlies diverse ion channelopathies and represents
an unexploited unifying principle for developing common treatments for otherwise dissimilar …

The light responses of rod and cone photoreceptors have been studied
electrophysiologically for decades, largely with ex vivo approaches that disrupt the …

Obesity is a major risk factor for the development of life-threatening malignant ventricular
tachyarrhythmias (VT) and sudden cardiac death (SCD). Risks may be highest for patients …

Inhibiting high-voltage-activated calcium channels (HVACCs; CaV1/CaV2) is therapeutic for
myriad cardiovascular and neurological diseases. For particular applications, genetically …