The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

Neural circuitry has evolved to form distributed networks that act dynamically across large
volumes. Conventional microscopy collects data from individual planes and cannot sample …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Light-based in-vivo brain imaging relies on light transport over large distances of highly
scattering tissues. Scattering gradually reduces imaging contrast and resolution, making it …

Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Developments in miniaturized microscopes have enabled visualization of brain activities
and structural dynamics in animals engaging in self-determined behaviors. However, it …

Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain
structures represents an important step toward the goal of understanding the mammalian …

A major open challenge in neuroscience is the ability to measure and perturb neural activity
in vivo from well defined neural sub-populations at cellular resolution anywhere in the brain …

Basal amygdala (BA) neurons guide associative learning via acquisition of responses to
stimuli that predict salient appetitive or aversive outcomes. We examined the learning-and …

Deciphering neurologic function is a daunting task, requiring understanding the neuronal
networks and emergent properties that arise from the interactions among single neurons …