Although progesterone is a steroid hormone mainly associated with female reproductive
functions, such as uterine receptivity and maintenance of pregnancy, accumulating data …

Background As in other types of cancers, sex is an essential factor in the origin and
progression of glioblastomas. Research in the field of endocrinology and cancer suggests …

Complex mechanisms involved in neuropathic pain that represents a major health concern
make its management complicated. Because neurosteroids are bioactive steroids …

Objective Allopregnanolone (Allo) is a neurosteroid with pleiotropic action in the brain that
includes neurogenesis, oligogenesis, human and rodent neural stem cell regeneration …

Glioblastoma (GBM) is the most aggressive local brain tumor and effective treatments are
lacking. Many studies have proposed an important participation of steroid hormones in the …

The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …

Background and aims Glioblastoma is the most frequent and aggressive brain tumor due to
its high capacity to migrate and invade normal brain tissue. The steroid hormone …

Progesterone induced blocking factor (PIBF) is a unique protein that is not present in normal
cells, but is found predominantly in rapidly growing cells of the fetal placental unit or cancer …

Allopregnanolone (3α-THP) has been one of the most studied progesterone metabolites for
decades. 3α-THP and its synthetic analogs have been evaluated as therapeutic agents for …

Introduction Glioblastomas (GBM) are the most frequent and aggressive human brain tumors
due to their high capacity to migrate, invade healthy brain tissue, and resist anticancer …