To maintain the stability and integrity of cellular genomic DNA, DNA repair enzymes catalyze
the repair of DNA damage caused by exogenous and endogenous factors through various …

Uracil‐DNA glycosylases (UDGs) are evolutionarily conserved DNA repair enzymes that
initiate the base excision repair pathway and remove uracil from DNA. The UDG superfamily …

For all living organisms, genome stability is important, but is also under constant threat
because various environmental and endogenous damaging agents can modify the structural …

Abstract Together with Bacteria and Eukarya, Archaea represents one of the three domain of
life. In contrast with the morphological difference existing between Archaea and Eukarya …

Uracil in DNA arises by misincorporation of dUMP during replication and by hydrolytic
deamination of cytosine. This common lesion is actively removed through a base excision …

Base moieties in DNA are spontaneously threatened by naturally occurring chemical
reactions such as deamination, hydrolysis and oxidation. These DNA modifications have …

High-temperature stress is critical for all organisms and induces a profound cellular
response. For Crenarchaeota, little information is available on how heat shock affects …

Genomes of hyperthermophiles are facing a severe challenge due to increased deamination
rates of cytosine induced by high temperature, which could be counteracted by base …

Oxidatively damaged bases in DNA cause many types of deleterious effects. The main
enzyme that removes such lesions is DNA glycosylase, and accordingly, DNA glycosylase …

Abstract Methyl-CpG-binding domain 4 (MBD4) DNA glycosylase is involved in excision of
spontaneous deamination products of cytosine and 5-methylcytosine in animals, but it is …