Reinvigorating exhausted CD8+ cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy

MA Hossain, G Liu, B Dai, Y Si, Q Yang… - Medicinal Research …, 2021 - Wiley Online Library
Immunotherapy has revolutionized the treatment of cancer in recent years and achieved
overall success and long‐term clinical benefit in patients with a wide variety of cancer types …

Oncolytic viruses combined with immune checkpoint therapy for colorectal cancer is a promising treatment option

Y Ren, JM Miao, YY Wang, Z Fan, XB Kong… - Frontiers in …, 2022 - frontiersin.org
Immunotherapy is one of the promising strategies in the treatment of oncology. Immune
checkpoint inhibitors, as a type of immunotherapy, have no significant efficacy in the clinical …

The Role of TIM-3 and LAG-3 in the Microenvironment and Immunotherapy of Ovarian Cancer

M Kozłowski, D Borzyszkowska, A Cymbaluk-Płoska - Biomedicines, 2022 - mdpi.com
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The main
treatment options are surgical removal of the tumor and chemotherapy. Cancer treatment …

Immunotherapies catering to the unmet medical need of cold colorectal cancer

J Yuan, J Li, C Gao, C Jiang, Z Xiang, J Wu - Frontiers in Immunology, 2022 - frontiersin.org
As a common malignant tumor of gastrointestinal tract, the incidence of colorectal cancer
(CRC) has gradually increased in recent years. In western developed countries, it has even …

Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential

R Saleh, SM Toor, E Elkord - Expert Opinion on Therapeutic …, 2020 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have shown a great therapeutic
efficacy in cancer patients. However, a significant proportion of cancer patients remain …

[HTML][HTML] The mechanism of LncRNA01977 in lung adenocarcinoma through the SDF-1/CXCR4 pathway

XR Lai, CL Wang, FZ Qin - Translational Cancer Research, 2022 - ncbi.nlm.nih.gov
Background A significant correlation has been identified between lncRNA and tumor cell
resistance, diagnosis, and prognosis. Although mRNA studies have dominated the field of …

Myeloid cells in circulation and tumor microenvironment of colorectal cancer patients with early and advanced disease stages

SM Toor, S Khalaf, K Murshed… - Journal of …, 2020 - Wiley Online Library
Myeloid‐derived suppressor cells (MDSCs) are a heterogenous population of cells that have
been implicated in the development of an immunosuppressive environment, which promotes …

Immune checkpoint inhibitors: breakthroughs in cancer treatment

X Kong, J Zhang, S Chen, X Wang, Q Xi… - Cancer Biology & …, 2024 - cancerbiomed.org
Over the past two decades, immunotherapies have increasingly been considered as first-
line treatments for most cancers. One such treatment is immune checkpoint blockade (ICB) …

Interaction of the Immune System TIM‐3 Protein with a Model Cellular Membrane Containing Phosphatidyl‐Serine Lipids

A Delova, A Pasc, A Monari - Chemistry–A European Journal, 2024 - Wiley Online Library
T cell transmembrane, Immunoglobulin, and Mucin (TIM) are important immune system
proteins which are especially present in T‐cells and regulated the immune system by …

[HTML][HTML] Co-expression of PD-1 with TIGIT or PD-1 with TIM-3 on tumor-infiltrating CD8+ T cells showed synergistic effects on improved disease-free survival in …

A Meyiah, GM Chalbatani, MA Al-Mterin… - International …, 2023 - Elsevier
Immune checkpoints (ICs) are highly expressed on tumor-infiltrating immune cells (TIICs) in
different malignancies, including colorectal cancer (CRC). T cells play crucial roles in …