Nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract,
causing widespread morbidity and mortality. Although mechanisms of damage involve the …

Background The short‐term gastric damage seen with non‐steroidal anti‐inflammatory
drugs (NSAIDs) in man may involve inhibition of cyclooxygenase (COX‐1) and COX‐2 as …

Background: The pathogenesis of NSAID‐induced gastrointestinal damage is believed to
involve a nonprostaglandin dependent effect as well as prostaglandin dependent effects …

Background & Aims: The pathogenesis of nonsteroidal anti-inflammatory drug–induced
enteropathy is controversial, but it is thought that cyclooxygenase-1 (COX-1) inhibition is of …

Non-steroidal anti-inflammatory drugs cause small-bowel inflammation in about 60% of
patients receiving these drugs long-term. The inflammation is associated with small …

Prolonged maternal separation in rats has several effects on health and behavior. Here we
investigated how maternal separation might interact with social stress in adulthood on …

Objective Uncoupling of isolated mitochondria by nonsteroidal antiinflammatory drugs
(NSAIDs) has been considered relevant to the development of gastrointestinal (GI) side …

BACKGROUND The pathogenesis of non-steroidal anti-inflammatory drug (NSAID)
enteropathy is complex. It involves uncoupling of mitochondrial oxidative phosphorylation …

Background Oral ferrous iron therapy may reinforce intestinal inflammation. One possible
mechanism is by catalyzing the production of reactive oxygen species. We studied the …

Background: It is suggested that the gastrointestinal toxicity of conventional non-steroid anti-
inflammatory drugs (NSAIDs) is due to a'topical'effect in addition to inhibition of the mucosal …