Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications

Z Liu, T Zhou, AC Ziegler, P Dimitrion… - Oxidative medicine and …, 2017 - Wiley Online Library
Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative
disorders. These diseases are normally characterized by progressive loss of neuron cells …

Spinocerebellar ataxia: an update

R Sullivan, WY Yau, E O'Connor, H Houlden - Journal of neurology, 2019 - Springer
Spinocerebellar ataxia (SCA) is a heterogeneous group of neurodegenerative ataxic
disorders with autosomal dominant inheritance. We aim to provide an update on the recent …

Kv3 channels: enablers of rapid firing, neurotransmitter release, and neuronal endurance

LK Kaczmarek, Y Zhang - Physiological reviews, 2017 - journals.physiology.org
The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Gait variability in spinocerebellar ataxia assessed using wearable inertial sensors

VV Shah, R Rodriguez‐Labrada, FB Horak… - Movement …, 2021 - Wiley Online Library
Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …

Endocannabinoids and neurodegenerative disorders: Parkinson's disease, Huntington's chorea, Alzheimer's disease, and others

J Fernández-Ruiz, J Romero, JA Ramos - Endocannabinoids, 2015 - Springer
This review focuses on the role of the endocannabinoid signaling system in controlling
neuronal survival, an extremely important issue to be considered when developing new …

Assessment of ataxia rating scales and cerebellar functional tests: critique and recommendations

S Perez‐Lloret, B Van de Warrenburg… - Movement …, 2021 - Wiley Online Library
Background We assessed the clinimetric properties of ataxia rating scales and functional
tests, and made recommendations regarding their use. Methods A systematic literature …

Juvenile parkinsonism: Differential diagnosis, genetics, and treatment

N Niemann, J Jankovic - Parkinsonism & related disorders, 2019 - Elsevier
Juvenile parkinsonism is arbitrarily defined as parkinsonian symptoms and signs presenting
prior to 21 years of age. Levodopa-responsive juvenile parkinsonism that is consistent with …

Ataxia in children: early recognition and clinical evaluation

P Pavone, AD Praticò, V Pavone, R Lubrano… - Italian Journal of …, 2017 - Springer
Background Ataxia is a sign of different disorders involving any level of the nervous system
and consisting of impaired coordination of movement and balance. It is mainly caused by …

[HTML][HTML] Neurotheranostics as personalized medicines

BD Kevadiya, BM Ottemann, MB Thomas… - Advanced Drug Delivery …, 2019 - Elsevier
The discipline of neurotheranostics was forged to improve diagnostic and therapeutic
clinical outcomes for neurological disorders. Research was facilitated, in largest measure …

Development, circuitry, and function of the zebrafish cerebellum

S Pose-Méndez, P Schramm, K Valishetti… - Cellular and Molecular …, 2023 - Springer
The cerebellum represents a brain compartment that first appeared in gnathostomes (jawed
vertebrates). Besides the addition of cell numbers, its development, cytoarchitecture …