Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Q Hu, S Zhang, Y Yang, JQ Yao, WF Tang… - Military Medical …, 2022 - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-
threatening lung diseases associated with acute and severe inflammation. Both have high …

Non-coding RNAs and exosomes: their role in the pathogenesis of sepsis

SMR Hashemian, MH Pourhanifeh, S Fadaei… - … Therapy-Nucleic Acids, 2020 - cell.com
Sepsis is characterized as an uncontrolled host response to infection, and it represents a
serious health challenge, causing excess mortality and morbidity worldwide. The discovery …

[HTML][HTML] Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling

J Zhang, C Chen, B Hu, X Niu, X Liu… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Chronic skin wounds represent one of the most common and disabling complications of
diabetes. Endothelial progenitor cells (EPCs) are precursors of endothelial cells and can …

COVID‐19 diagnostic testing: technology perspective

M Xu, D Wang, H Wang, X Zhang… - Clinical and …, 2020 - Wiley Online Library
The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). More than 18 million …

Role of miRNA dysregulation in sepsis

A Formosa, P Turgeon, CC Dos Santos - Molecular Medicine, 2022 - Springer
Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a
dysregulated host response to infection and causes millions of deaths worldwide annually …

Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126

X Wu, Z Liu, L Hu, W Gu, L Zhu - Experimental cell research, 2018 - Elsevier
Endothelial progenitor cell (EPC) has potential to attenuate pulmonary inflammation and
injury. As a pivotal paracrine entity of stem cells, whether EPC-derived exosomes (EPC …

microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-κB signaling pathway

J Sun, X Sun, J Chen, X Liao, Y He, J Wang… - Stem cell research & …, 2021 - Springer
Abstract Background Exosomal microRNAs (miRs) derived from mesenchymal stem cells
(MSCs) have been shown to play roles in the pathophysiological processes of sepsis …

MicroRNAs as clinical biomarkers and therapeutic tools in perioperative medicine

S Kreth, M Hübner, LC Hinske - Anesthesia & Analgesia, 2018 - journals.lww.com
RNA-induced silencing complex recognizes its target mRNA through Watson-Crick
complementarity of its 5′-end to the 3′-UTR of its target (Figure 1B). Whereas in plants …

[HTML][HTML] Molecular mechanisms of organ damage in sepsis: an overview

G Sygitowicz, D Sitkiewicz - Brazilian Journal of Infectious Diseases, 2021 - SciELO Brasil
Sepsis is one of the most common reasons for hospitalization. This condition is
characterized by systemic inflammatory response to infection. International definition of …

Role of microRNAs in sepsis

SMK Kingsley, BV Bhat - Inflammation Research, 2017 - Springer
Introduction MicroRNAs have been found to be of high significance in the regulation of
various genes and processes in the body. Sepsis is a serious clinical problem which arises …