The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD+)
biosynthesis, which contributes to metabolic dysfunction. Nicotinamide mononucleotide …

Evidence from observational studies and randomized trials suggests that prediabetes and
type 2 diabetes mellitus (T2DM) can develop in genetically susceptible individuals in …

Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue
in human participants. The most frequently used methodologies to evaluate insulin …

Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to
its ability to dissipate energy as heat. Despite a plethora of data concerning the role of BAT …

Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …

Background Some studies have suggested that in people with type 2 diabetes, Roux-en-Y
gastric bypass has therapeutic effects on metabolic function that are independent of weight …