Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Exposure to air pollution in relation to risk of dementia and related outcomes: an updated systematic review of the epidemiological literature

J Weuve, EE Bennett, L Ranker… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Dementia is a devastating neurologic condition that is common in older adults.
We previously reviewed the epidemiological evidence examining the hypothesis that long …

Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach

A Nandi, N Counts, S Chen, B Seligman… - …, 2022 - thelancet.com
Summary Background The burden of Alzheimer's disease and related dementias (ADRDs)
is expected to grow rapidly with population aging, especially in low-and middle-income …

Neuroprotective herbs for the management of Alzheimer's disease

J Gregory, YV Vengalasetti, DE Bredesen, RV Rao - Biomolecules, 2021 - mdpi.com
Background—Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative
disease that is characterized by memory loss, personality changes, and a decline in …

Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis

JL Liss, S Seleri Assunção, J Cummings… - Journal of internal …, 2021 - Wiley Online Library
The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention,
diagnosis and management must evolve as new treatment paradigms and disease …

Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers

M Habashi, S Vutla, K Tripathi… - Proceedings of the …, 2022 - National Acad Sciences
Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …

The humanistic and economic burden of Alzheimer's disease

AA Tahami Monfared, MJ Byrnes, LA White… - Neurology and …, 2022 - Springer
Alzheimer's disease (AD) is the leading cause of cognitive impairment and dementia in older
individuals (aged≥ 65 years) throughout the world. As a result of these progressive deficits …

[HTML][HTML] Promoting successful cognitive aging: a ten-year update

TJ Krivanek, SA Gale, BM McFeeley… - Journal of …, 2021 - content.iospress.com
A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

[HTML][HTML] Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related …

LA Manwell, M Tadros, TM Ciccarelli… - Journal of integrative …, 2022 - imrpress.com
Converging evidence from biopsychosocial research in humans and animals demonstrates
that chronic sensory stimulation (via excessive screen exposure) affects brain development …

Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease

SS Assunção, RA Sperling, C Ritchie… - Alzheimer's research & …, 2022 - Springer
Background The need for preventive therapies that interrupt the progression of Alzheimer's
disease (AD) before the onset of symptoms or when symptoms are emerging is urgent and …