Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Image-guided cancer surgery using near-infrared fluorescence

AL Vahrmeijer, M Hutteman, JR Van Der Vorst… - Nature reviews Clinical …, 2013 - nature.com
Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster,
better and less expensively than current standards. Optical imaging that exploits invisible …

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

GM Van Dam, G Themelis, LMA Crane, NJ Harlaar… - Nature medicine, 2011 - nature.com
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific
intraoperative fluorescence imaging may improve staging and debulking efforts in …

The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery

BE Schaafsma, JSD Mieog, M Hutteman… - Journal of surgical …, 2011 - Wiley Online Library
Optical imaging using near‐infrared (NIR) fluorescence provides new prospects for general
and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer‐related surgery …

[HTML][HTML] Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology

C Chi, Y Du, J Ye, D Kou, J Qiu, J Wang, J Tian… - Theranostics, 2014 - ncbi.nlm.nih.gov
Cancer is a major threat to human health. Diagnosis and treatment using precision medicine
is expected to be an effective method for preventing the initiation and progression of cancer …

Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation

S Gioux, HS Choi, JV Frangioni - Molecular imaging, 2010 - journals.sagepub.com
The field of biomedical optics has matured rapidly over the last decade and is poised to
make a significant impact on patient care. In particular, wide-field (typically> 5 cm), planar …

Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin

M Van Oosten, T Schäfer, JAC Gazendam… - Nature …, 2013 - nature.com
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and
treat. Here, guided by recent advances in clinically relevant optical imaging technologies …

Optical image-guided cancer surgery: challenges and limitations

S Keereweer, PBAA Van Driel, TJA Snoeks… - Clinical Cancer …, 2013 - AACR
Optical image-guided cancer surgery is a promising technique to adequately determine
tumor margins by tumor-specific targeting, potentially resulting in complete resection of …

Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging …

HG van der Poel, T Buckle, OR Brouwer, RAV Olmos… - European urology, 2011 - Elsevier
BACKGROUND: Integration of molecular imaging and in particular intraoperative image
guidance is expected to improve the surgical accuracy of laparoscopic lymph node (LN) …

Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: a single-centre feasibility study

NJ Harlaar, M Koller, SJ de Jongh… - The Lancet …, 2016 - thelancet.com
Background Optimum cytoreductive surgery combined with hyperthermic intraperitoneal
chemotherapy (HIPEC) is essential for the curative treatment of peritoneal carcinomatosis of …