Idebenone is a well described drug that was initially developed against dementia. The
current literature widely portrays this molecule as a potent antioxidant and CoQ 10 …

Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …

Wolfram syndrome 1 (WS1) is a rare neurodegenerative disease transmitted in an
autosomal recessive mode. It is characterized by diabetes insipidus (DI), diabetes mellitus …

Objective ALS is a rapidly progressive, fatal disorder caused by motor neuron degeneration,
for which there is a great unmet therapeutic need. AMX0035, a combination of sodium …

The neuronal endoplasmic reticulum (ER) consists of a dynamic, tubular network that
extends all the way from the soma into dendrites, axons, and synapses. This morphology …

Background Although the advent of combination anti-retroviral therapy (cART) has
transformed HIV into a manageable chronic disease, an estimated 30–50% of people living …

Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger
cytoprotective, or cell death pathways. Mitochondrial homeostasis and function decline with …

Aims/hypothesis Wolfram syndrome is a rare autosomal recessive disorder caused by
pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes …

Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of
various cellular processes. Mitochondrial dysfunctions have been directly linked to …

Mutations in WFS1 (which encodes Wolframin, WFS1) and CISD2 (which encodes CDGSH
iron sulfur domain 2) result in Wolfram syndrome (WS), a rare genetic disorder that starts …